The film lacks explicit queer romantic arcs or centered LGBTQ+ identities. However, it avoids heteronormative tropes by focusing on unconventional interpersonal connections and avoids derogatory depictions.

Women serve as primary plot drivers with significant agency. Characters like Amanda Waller, Harley Quinn, and Ratcatcher 2 are depicted as intellectually and physically dominant, avoiding submissive femininity.

The ensemble features a multicultural cast, including Michael Jai White as Bloodsport. The setting of Corto Maltese provides a post-colonial backdrop that acknowledges non-Western sovereignty and geopolitical complexities.

The narrative critiques Western institutional power and government overreach. It emphasizes 'found family' structures over traditional patriotic or biological frameworks, presenting a sophisticated view of moral relativism.

The film lacks explicit depictions of neurodivergence or physical disability. Non-human entities like King Shark function as metaphors for 'otherness,' but specific disability agency is absent.