The film engages with non-normative desires and fetishism. While explicit same-sex identities are not confirmed, the focus on madness and metamorphosis suggests a departure from heteronormative stability.

Experiments on human guinea pigs likely prioritize biological imperatives over traditional gender roles. The narrative offers potential for subverting hierarchies through the shared vulnerability of its subjects.

As a Japanese production, the film provides a non-Western perspective. It moves away from Hollywood-centric norms, utilizing a stylized cyberpunk aesthetic that de-emphasizes traditional ethnic markers.

The film challenges Western institutional norms through themes of madness and scientific authority. Its surrealist, black-and-white aesthetic rejects polished, conventional cinematic values in favor of chaotic reality.

Themes of metamorphosis and neurochemical manipulation engage with atypical bodies. It remains unclear if these physical transformations grant characters agency or serve purely as horror tropes.