The film lacks explicit mention of LGBTQ+ characters or non-cisnormative identities. However, the narrative likely explores themes of bodily autonomy and non-traditional existence through its subversion of biological norms.

The story centers on the intellect and ego of Dr. Victor Frankenstein. Del Toro's direction likely deconstructs the mad scientist trope to highlight the fragility of patriarchal control.

The production's specific casting choices remain unconfirmed, leaving the racial landscape uncertain. While the source material is Eurocentric, the director's history suggests potential for an expansive, diverse ensemble.

The film critiques Enlightenment-era scientific hubris and individualistic mastery over nature. It likely prioritizes a post-humanist perspective, framing the creature as a systemic victim rather than a moral agent of evil.

The creature serves as a profound exploration of physical difference and neurodivergence. The film grants agency to a sentient being existing outside the bounds of physical normalcy.