The film lacks explicit queer characters or non-heteronormative romantic arcs. The narrative focus stays on the central tension between Hellboy and Liz Sherman.

Liz Sherman serves as a capable agent with significant pyrokinesis. She avoids the damsel in distress trope, acting as a central pillar of the tactical unit.

The film uses non-human species as metaphors for ethnic diversity. The B.P.R.D. ensemble explores themes of belonging through a diverse, supernatural lens.

The story critiques fascist ideologies through the lens of malevolent mysticism. It contrasts corruptive occultism with the pragmatic protection of an institutionalized agency.

Physical divergence is treated with dignity rather than mockery. Characters like Abe Sapien possess bodies that deviate from human norms without being framed as defects.