The film lacks LGBTQ+ characters or narratives. Interpersonal dynamics focus on the protagonist's isolation and her eventual detachment from human social structures.

Lucy disrupts gender hierarchies by evolving from a vulnerable victim of male-driven crime into a near-omnipotent entity. Her intellectual and physical dominance renders male antagonists irrelevant.

The Taipei setting and East Asian cast, including the antagonist Mr. Jang, move the film away from Anglo-centric perspectives. However, the white protagonist remains the central focus.

The narrative prioritizes scientific mysticism over religious morality, embracing a moral relativism that transcends conventional ethics. It critiques the commodification of the body within global capitalism.

Neurodivergence and altered states are used as plot devices to trigger superhuman abilities. These elements lack nuanced portrayals of lived disability or actual neurodiversity.