The film lacks LGBTQ+ characters or non-heteronormative narratives. Interpersonal dynamics focus on a traditional romantic pairing between the protagonist and Constance.

Constance demonstrates significant agency and leadership as a primary decision-maker. However, the narrative ultimately centers on the masculine survivalist archetype of Robert Neville.

Casting is predominantly white, reflecting the cinematic standards of 1971. The story focuses on biological distinctions between survivors and mutants rather than ethnic intersectionality.

The film explores the collapse of Western civilization and the loss of structured law. It portrays the breakdown of the family unit as a cautionary tale.

Physical deformity and light sensitivity are used as plot devices to mark antagonists. These traits are framed as predatory rather than lived experiences of disability.