The film centers on the historical romantic partnership between Marie and Pierre Curie. It operates within a conventional heteronormative framework with no depiction of non-cisnormative identities.

Marie Skłodowska-Curie is portrayed with immense cognitive strength and professional autonomy. The narrative disrupts 19th-century hierarchies by making her scientific agency a primary driver of the plot.

The cast is predominantly white, reflecting the demographic realities of late 19th-century France. The film does not utilize color-blind casting or diverse ethnic perspectives.

The story prioritizes empirical discovery and a secular, Enlightenment-based worldview. It remains rooted in Western intellectual traditions without explicitly critiquing Western institutions.

There are no prominent depictions of visible or invisible disabilities. No character arcs are defined by neurodivergence or physical impairment.